THE SMART TRICK OF PKRRATING THAT NOBODY IS DISCUSSING

) mechanism16,30–34 [for just a contrary look at see35]. The BTB dimer orients the Energetic internet sites clear of the dimer interface in the configuration that can't mediate this response. Here, we report buildings of wild-kind, unphosphorylated PKR kinase. The kinase domains interact via the BTB interface and adopt an Lively conformation from